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Two Infants Treated with Universal Immune Cells Have Their Cancer Vanish

Two Infants Treated with Universal Immune Cells Have Their Cancer Vanish

In a medical first, the children were treated with genetically engineered T-cells from another person.

by Antonio Regalado January 25, 2017

Doctors in London say they have cured two babies of leukemia in the world’s first attempt to treat cancer with genetically engineered immune cells from a donor. The experiments, which took place at London’s Great Ormond Street Hospital, raise the possibility of off-the-shelf cellular therapy using inexpensive supplies of universal cells that could be dripped into patients’ veins on a moment’s notice.

The …

Polio virus for Glioblastoma Multiforme

What ’60 Minutes’ Got Right And Wrong On Duke’s Polio Virus Trial Against Glioblastoma
by David Kroll on Forbes.com

An engineered version of the poliovirus has been in development for more than 20 years as a treatment for one of the most difficult-to-treat cancers, a brain tumor called glioblastoma multiforme, abbreviated GBM. A human safety trial of the virus, called a Phase I study, is ongoing at Duke University’s Brain Tumor Center in Durham, North Carolina. The patients who’ve been enrolled have the toughest form of this disease: GBM that has returned after previous surgery and treatment.

Last night, the …

New Treatment for Advanced Leukemia (I told you so)

From Sky News

Tests of a potentially revolutionary cancer therapy have had “extraordinary” results on terminally ill patients, scientists have revealed.

In one study, more than nine out of ten participants with a severe form of leukaemia saw their symptoms completely vanish.

Four out of five patients with some other blood cancers responded positively to the treatment and more than half ended up symptom free.

Lead scientist Professor Stanley Riddell, from the Fred Hutchinson Cancer Research Center in Seattle, US, said the results were among patients who were projected to have two to five months to live.

He said: “This is extraordinary. This …

Incremental Advance in Immune Therapy for Melanoma

[Though not as striking as the abscopal effect stories that have come out recently in the context of metastatic melanoma, this story advances the notion that immune modulation is a viable approach to a generalizable treatment for cancer.   Although my hypothesis is that patient specific immune modulation (targeting the patient’s actual tumor markers and pointing the immune system in the right direction) will be the eventual answer, drug companies want to at least try to develop something general that they can sell.   We’ll see if this approach is just a stepping stone to a more complete general treatment or …

Abscopal Effect and Malignant Melanoma

[This one is a rare effect, but if they can just figure out how to trigger it consistently (research is ongoing) this would be a kickass weapon in the war against malignant melanoma and some other cancers.   A more general article on the abscopal effect can be found on Wikipedia, but here’s a quickie from Oncology Nurse Advisor.   –dr steve]

A recent melanoma case featuring the abscopal effect, in which local radiotherapy delivered to a single tumor results in the regression of metastatic cancer at a distance from the irradiated site, may lay the groundwork …

Measles and Multiple Myeloma

[Another interesting idea…if you know someone with refractory multiple myeloma, they may qualify for a clinical trial in vaccine therapy (take THAT, anti-vaxxers!)  –dr steve]

from cnn.com

A woman with an incurable cancer is now in remission, thanks, doctors say, to a highly concentrated dose of the measles virus.

For 10 years, Stacy Erholtz, 49, battled multiple myeloma, a deadly cancer of the blood. Doctors at the Mayo Clinic say she had received every type of chemotherapy drug available for her cancer and had undergone two stem cell transplants, only to relapse time …

Striking Results With T-Cell Immunotherapy in Cervical Cancer

[I used to say we were 100 years away from a more generalized approach to cancer therapy.  In the end, barring some unforeseen breakthrough, cancer “cures” will come from the realm of immunology.  The immune system is perfectly appointed to eradicate cancer cell by cell, molecule by molecule, but it only works if it actually recognizes the cancer as abnormal.  Turning on the immune system to recognize cancer cells as foreign is the purpose of a lot of research right now and this is the outcome of a small pilot study.  This makes me think the time horizon is …

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